Andrea Saltelli has worked on physical chemistry, environmental sciences, applied statistics, impact assessment and science for policy. His main disciplinary focus is on sensitivity analysis of model output, a discipline where statistical tools are used to interpret the output from mathematical or computational models, and on sensitivity auditing, an extension of sensitivity analysis to the entire evidence-generating process in a policy context.

His most recent papers have tackled sensitivity analysis and auditing, the ecological footprint, the future of statistics, the rational of evidence-based policy, the crisis of science and the post-truth discussion. Andrea gives courses in sensitivity analysis, sensitivity auditing, science integrity, and ethics of quantification. He has recently published on the role of science in processes of regulatory capture.